Programme

• Monday
  26 June MON
  26 JUN
• Tuesday
  27 June TUE
  27 JUN
• Wednesday
  28 June WED
  28 JUN
• List of
  Posters List of
  Posters
  List
  of
  Posters
  

• 12:00-13:30	Pre-conference light buffet
  13:30-14:00	Opening Remarks and Institutional Welcome
  Session I - Genomic Landscape and Architecture CHAIRS: Valeria Poli, Graziano Pesole
  14:00-14:30	Elzo de Wit, Netherlands Cancer Institute, Amsterdam, The Netherlands Functional dissection of the 3D genome
  14:30-14:45	Francesca Gorini, University of Naples 'Federico II', Italy The accumulation of 8-oxodG at super-enhancers marks fragile CTCF-mediated chromatin loops
  14:45-15:00	Alessandro Bertero, University of Turin, Italy Dysregulated 3D chromatin structure mechanism in congenital heart disease revealed by chamber-specific cardiac organoids
  15:00-15:15	Giulia Buonaiuto, Sapienza University of Rome, Italy From mouse to human: how RNA epigenetic influences cardiomyocytes maturation
  15:15-15:30	Federico Lazzaro, University of Milan, Italy Counteracting G-quadruplex-induced genome instability
  15:30-16:00	Marcelo Nollmann, Centre de Biochimie Structurale, INSERM/CNRS, Montpellier, France Inspecting roles of 3D chromatin organization in transcription by multiplexed imaging
  16:00-16:15	Francesco Nicassio, IIT, Milan, Italy Transcriptional, epigenetic and genetic determinants triggering distinct cancer phenotypes coexist in the same cancer population
  16:15-16:30	Sara Pini, University of Modena and Reggio Emilia, Italy A human pan-genomic analysis provides insights into the genetic and epigenetic complexity of phenotypes associated with facioscapulohumeral muscular dystrophy
  16:30-16:45	Davide Bressan, CIBIO, Trento, Italy Increased genomic instability and reshaping of tissue microenvironment drive ARID1A-dependent cancer formation
  16:45-17:00	Renée Duardo, University of Bologna, Italy Topoisomerase I-DNA cleavage complexes induce genome instability at early replicating DNA loop anchors
  17:00-19:00	Poster Session 1 and coffee break
  19:00-20:30	Symposium: Science and Society Research Integrity and Open Science Emma Lazzeri (GARR, Italy) Alicia Estacio Gómez (Open Research Europe, F1000. United Kingdom)
  20:30	Welcome Cocktail in the garden

• Session II - Epigenomics CHAIRS: Lucia Altucci, Salvatore Oliviero
  9:00-9:30	Tiziana Bonaldi, IEO, Milan, Italy A proteomic perspective on the role of protein methyltransferases in cancer heterogeneity and plasticity
  9:30-9:45	Elena Di Nisio, Sapienza University of Rome, Italy A truncated and catalytically inactive isoform of KDM5B histone demethylase accumulates in breast cancer cells and regulates H3K4 tri-methylation and gene expression
  9:45-10:00	Artem Smirnov, University of Rome 'Tor Vergata', Italy Epigenetic priming of an epithelial enhancer by p63 and CTCF controls expression of a skin-restricted gene XP33
  10:00-10:15	Francesca Guarino, University of Catania, Italy VDAC1 gene promoter regulation: exploring transcription factors functionality and genome methylation
  10:15-10:30	Masoumeh ElyasiDashtaki, University of Insubria, Italy UHRF1 is a better prognostic factor in colorectal and gastric cancers and thymoma by negatively regulating EMT factors and cancer stemness pathway genes
  10:30-11:00	Coffee break
  Session III - Biomolecular Condensates CHAIRS: Tiziana Bonaldi, Gianni Cuda
  11:00-11:30	Simon Alberti, Technische Universität Dresden, Germany Biomolecular condensates in health and disease
  11:30-11:45	Serena Carra, University of Modena and Reggio Emilia, Italy Small HSPs as molecular chaperones at the interface between proteins and lipids
  11:45-12:00	Francesco Panariello, TIGEM, Pozzuoli, Italy A paracrine HGF-MET-STAT3 axis oversees cellular transition towards human pluripotency
  12:00-12:15	Elena Carbognin, University of Padua, Italy Esrrb guides naive pluripotent cells through the formative transcriptional programme
  12:15-12:30	Lavinia Grasso, University of Milan, Italy DNA polymerase η, ribonucleotides and Nanopore sequencing: a story of replication stress
  12:30-14:00	Short Talks By Illumina (Paolo Caiella) and Carlo Erba (Daniele Zeni)
  12:30-14:00	Lunch
  Session IV - RNA Metabolism and Epitranscriptomics CHAIRS: Serena Carra, Ernesto Picardi
  14:00-14:30	Michael Jantsch, Medical University of Vienna, Austria Regulating innate immunity via RNA-editing
  14:30-14:45	Luca La Via, University of Brescia, Italy RNA editing of CYFIP2 regulates actin related cellular migration and neuronal development in vitro
  14:45-15:00	Toma Tebaldi, University of Trento, Italy Inhibition of METTL3 and m6A induces accumulation of endogenous double-stranded RNAs and innate immune response
  15:00-15:15	Sajid Amin, University of Campania 'Luigi Vanvitelli', Naples, Italy ZC3H13 is a crucial target involve in the survival of AML
  15:15-15:30	Michela Lo Conte, Magna Græcia University, Catanzaro, Italy The ZZZ3, a subunit of the ATAC complex, is important for human ESCs homeostasis, self-renewal, and regulation of ribosome biogenesis
  15:30-17:30	Poster Session 2 and coffee break
  17:30-18:00	Riccardo Cortese Lecture Irene Bozzoni, Sapienza University of Rome, Italy Decoding non-coding RNA function in physiology and pathology
  18:00-18:15	Ermes Filomena, University of Bari, Italy Providing new insights on non-coding RNAs involvement in Alzheimer’s disease through a comprehensive bioinformatic analysis based on Hippocampus and Fusiform Gyrus RNA-seq datasets
  18:15-18:30	Fabio Desideri, IIT, Rome, Italy RNA-RNA interactions at the onset of human motor neurons specification: CyCoNP lncRNA sustains NCAM1 expression by a direct-binding mechanism
  18:30-18:45	Chiara Barzan, CNR, Pavia, Italy A novel post-transcriptional circuit required for tumor angiogenesis and cancer growth
  18:45-19:00	Livia Caizzi, University of Turin, Italy Efficient RNA polymerase II pause release requires U2 snRNP function
  19:00-20:30	SIBBM members' general assembly
  20:30	Social dinner

• Session V - Gene Function and Therapeutic Applications CHAIRS: Michela A. Denti, Graziano Martello
  9:00-9:30	Mirko Pinotti, University of Ferrara, Italy Ribosome readthrough over premature termination codons: molecular mechanisms and pathophysiological implications for genetic disorders
  9:30-9:45	Daniela Di Girolamo, CEINGE, Naples, Italy Identification of a novel genome editing approach for the treatment of AEC syndrome
  9:45-10:00	Clara Zannino, Magna Græcia University, Catanzaro, Italy Low endogenous levels of heat shock protein beta-1 impair antioxidant response in patients carrying SCN1A mutations
  10:00-10:15	Laura Marchetti, University of Pisa, Italy Extracellular vesicles as carriers of RNA therapeutics: possible role of the p75NTR-NGF-TrkA ternary complex to support targeted delivery
  10:15-10:30	Ciro Iaccarino, University of Sassari, Italy Modulation of vesicle trafficking rescues Parkinson’s phenotype related to LRRK2 mutations
  10:30-11:00	Coffee break
  11:00-11:30	EMBL Lecture Nina Papavasiliou, German Cancer Research Centre (DKFZ), Heidelberg, Germany Targeted RNA editing as an enhancer of immunotherapy
  11:30-11:45	Domenico Liguoro, Sapienza University of Rome, Italy The interplay between miR-579-3p and MITF controls melanoma progression and resistance to targeted therapies
  11:45-12:00	Erica Gasparotto, INGM, Milan, Italy LINE1 expression dynamics in colorectal cancer sensitivity to DNA damage
  12:00-12:15	Lorena Quirico, MBC, Turin, Italy Axl-miR-214sponge chimeric aptamer reduces breast cancer and melanoma dissemination
  12:15-12:30	Marcella Cesana, TIGEM, Pozzuoli, Italy TFEB is a master regulator of syncytiotrophoblast formation in the placenta
  12:30-13:30	Prizes and Wrap-up

• The poster's maximum size is A0 (841 x 1189 mm; width x height).

  Correct format...    Wrong format...

  Posters with an odd number will be presented during Poster Session 1 (Monday, 26 June, 17:00-19:00). Posters with an even number will be presented during Poster Session 2 (Tuesday, 27 June, 15:30-17:30).

  P.1 Susanna Ambrosio, Naples
  Dissecting the relationship between DNA repair and autophagy to improve the efficacy of anticancer treatment

  P.2 Vito Antonio Amico, Rome
  The study of cross-kingdom regulation of plant microRNAs with possible anti-inflammatory and anti-tumor activity in human

  P.3 Mehrad Babaei, Naples
  METTL16 is a key target for chronic myeloid leukemia survival

  P.4 Michele Bissoli, Verona
  Human thioesterase ACOT8 has an impact on in vitro HIV-1 infectivity

  P.5 Chiara Bugelli, Turin
  Functional characterization of lncRNAs involved in epigenetic regulation of human neural development and neurological disorders in human brain organoids

  P.6 Carmen Caiazza, Naples
  8-oxodG accumulation within human mitochondrial genome associates with transcription

  P.7 Tiziana Castrignanò, Viterbo
  De novo transcriptome assembly and annotation for gene discovery in Salamandra salamandra at the larval stage

  P.8 Martina Coco, Turin
  MiR-148b regulates cell metabolism and affects tumor progression in melanoma and breast cancer

  P.9 Andrea Corsi, Verona
  Tau exon 6 alternative splicing is regulated by the RNA-binding proteins PTBP1 and RBM20

  P.10 Sharon Cox, Bari
  Development of a pipeline for identifying mito-nuclear variants in patients with amyotrophic lateral sclerosis using whole genome and exome sequencing data

  P.11 Claudia Crosio, Sassari
  Effects of cyanotoxins triggers in neurodegenerative cellular models

  P.12 Salvatore Cubisino, Catania
  Evaluation of ion channel activity of envelope protein E2 from SARS-CoV-2

  P.13 Eleonora D'Ambra, Rome
  Circ-Dlc1 KO affects long-term potentiation in cortical-striatum circuitry in vivo and in vitro

  P.14 Teresa Dalle Nogare, Trento
  Analysis of the expression profile of genes regulated by treatment with glucorticoids and retinoic acid in lung cancer

  P.15 Ilenia De Leo, Caserta
  RNA regulatory networks governed by miR-125a in hepatocarcinoma cells

  P.16 Benedetta Di Chiara Stanca, Lecce
  Analysis of Concentrated Growth Factors (CGFs): cell population and angiogenic potential

  P.17 Valeria Di Gioia, Milan
  LINE1 elements are novel epigenetic players of T cell quiescence through phase separation

  P.18 Anna Di Matteo, Pavia
  NOVA2 upregulation plays a pervasive role in alternative splicing changes of gastric cancer endothelium

  P.19 Elisa Ferracci, Povo (TN)
  Deciphering the role of the PR-Dub complex during liver homeostasis and regeneration

  P.20 Alessandro Ferrando, Trieste
  SFPQ controls genomic stability by suppressing RNA:DNA hybrids in human cancer cells

  P.21 Arianna Finizio, Naples
  Retargeted or attenuated Herpes Simplex Virus 1 genomes as a platform for arming strategies in cancer therapy

  P.22 Adriano Fonzino, Bari
  Detecting C-to-U RNA editing by direct RNA sequencing

  P.23 Davide Gabellini, Milan
  DUX4-r exerts a neomorphic activity that depends on a novel co-factor in acute lymphoblastic leukemia

  P.24 Umberto Galderisi, Naples
  Meta-analysis of senescent cell secretomes to identify common and specific features of the different senescent phenotypes: a tool for developing new senotherapeutics

  P.25 Paolo Gandellini, Milan
  The pancancer overexpressed NFYC antisense 1 controls cell cycle mitotic progression through in cis and in trans modes of action

  P.26 Laura Giannotti, Lecce
  Role of quercetin in the NAFLD treatment: reduction of lipid accumulation and inhibition of de novo fatty acid synthesis

  P.27 Meriem Hamadou, Trento
  Mining common genetic variants impacting on allele-specific translation and cancer risk

  P.28 Bablu Kumar, Milan
  Assessing gut microbiome health using integrative omics data analysis with machine learning predictions

  P.29 Erika Lorusso, Bari
  Development of a gut microbiome eubiosis/dysbiosis index based on DNA metabarcoding data by using Machine Learning approach

  P.30 Barbara Mandriani, Bari
  Tumor neoantigens shape the immune microenvironment of panNETs: an in silico analysis

  P.31 Stefania Martucciello, Fisciano (SA)
  The interaction between TBX1 and VEGFR3 in cardiac development

  P.32 Pietro Mazzacuva, Rome
  Detecting A-to-I RNA editing by Convolutional Neural Networks

  P.33 Angela Messina, Catania
  Analysis of human VDAC pseudogenes highlights an important role of VDAC1P8 pseudogene in acute myeloid leukemia (AML)

  P.34 Livio Muccillo, Benevento
  The Sp1-miR-27a-ZBTB10 axis mediates the molecular effects of quercetin in colorectal cancer cells

  P.35 Anna Noviello, Naples
  Analysis of the role of the nuclear lamina in genomic stability

  P.36 Francesca Orso, Novara
  miR-214 mediated stroma-tumor cell crosstalk during tumor progression

  P.37 Alessandro Palma, Rome
  Integration of transcriptomic data to dissect the role of long non coding RNAs in amyotrophic lateral sclerosis

  P.38 Filippo Passarino, Verona
  FGFR3-G375C associated with achondroplasia shows a novel kinase active isoform of 50 kDa

  P.39 Gerardo Pepe, Rome
  A feature-based meta-analysis approach to unravel the pathophysiological landscape of autoimmune diseases

  P.40 Francesca Cristiana Piritore, Verona
  Modulation of miR 146b-5p expression during the aging

  P.41 Anna Piscone, Naples
  8-oxodG and G4: deciphering the crosstalk between DNA damage and transcription regulation

  P.42 Elham Safadeh, Naples
  Alternative splicing and cancer epigenetic: BCLAF1 role in colorectal cancer

  P.43 Michele Sallese, Chieti
  A multi-omics approach to shed light on the pathogenetic mechanisms of Marinesco-Sjogren's syndrome

  P.44 Valentina Salsi, Modena
  FRG2A is part of a novel family of lncRNAs affecting nucleolus function in FSHD cells

  P.45 Antonella Sarnataro, Naples
  Dissecting DNA methylation patterns at single-molecule level through next-generation sequencing using EpiStatProfileR

  P.46 Elisabetta Sbisà, Bari
  CNRBiOmics and ELIXIRxNextGenIT: establishment and enhancement of the Integrative Omics platform of ELIXIR-IT, the Italian Node of the European Research Infrastructure for Life Sciences

  P.47 Eleonora Stanca, Lecce
  Cellular and molecular component of concentrated growth factor induced osteogenic differentiation and improved the osteointegration of dental implants

  P.48 Maria Letizia Taddei, Florence
  Metabolic adaptations driving 5-Fluorouracil resistance in colorectal cancer: PHGDH heterogeneity as a key driver

  P.49 Anna Vareschi, Verona
  RUNX2 promotes metastatic ability of melanoma cells by increasing CXCR4 expression

  P.50 Enza Maria Verde, Modena
  Loss of PML nuclear bodies in familial Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

  P.51 Zaibunnisa Zaibunnisa, Varese
  IGFL1 is a new ERG induced and secreted factor in prostate cancer with immune regulatory activity and clinical relevance

  P.52 Paola Zanfardino, Bari
  Mechanisms of pathogenicity in OPA1 deficient fibroblasts

  P.53 Sharazed Zouari, Verona
  Physical activity modulates miRNA expression in serum extracellular vesicles